A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/00 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2205780
The invention relates to the use of nonpeptide bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders (hepatic cirrhosis and hepatic fibrosis), acute liver disorders and for the prevention of complications, in particular for the prophylaxis or treatment of portal hypertension, decompensation symptoms such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulationand hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.
L'invention porte sur l'usage des antagonistes de la bradykinine pour la production de produits pharmaceutiques utilisés dans le traitement de maladies hépatiques fibrogènes chroniques (cirrhose hépatique et fibrose hépatique), des maladies hépatiques aiguës et pour la prévention de complications, en particulier pour la prophylaxie et le traitement de l'hypertension portale, des symptômes de décompensation comme l'ascite, l'oedème, le syndrome hépatorénal, la gastropathie hypertensive et la colopathie, la splénomégalie et les complications hémorragiques du tractus gastro-intestinal dues à l'hypertension portale, la circulation collatérale et l'hyperémie et une cardiopathie comme pouvant résulter d'une hyperdynamie circulatoire et ses conséquences.
Bickel Martin
Heitsch Holger
Hropot Max
Wagner Adalbert
Wirth Klaus
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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