N-phenylthiourea derivatives and pharmaceutical use thereof

Details N-phenylthiourea derivatives and pharmaceutical use thereof N-phenylthiourea derivatives and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

C

C07C 335/16 (2006.01) A61K 31/17 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/395 (2006.01) C07D 295/21 (2006.01)

Patent

CA 2072704

600-7152 A B S T R A C T: N-PHENYLTHIOUREA DERIVATIVES AND PHARMACEUTICAL USE THEREOF The invention concerns the use of the compounds of formula I Image I wherein the substituents have various significances, in free form or salt form as appropriate, in the treatment of atherosclerosis. It also concerns pharmaceutical compositions comprising a compound selected from a subgroup thereof. It further concerns a subgroup of compounds thereof, which are novel, per se. The compounds of formula I can be prepared in conventional manner, e.g. by reaction of an isothiocyanate with an amine or conversion of an urea to a thiourea.

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