C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2302525
The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In paricular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system- related disorders and disorders of the regulation of cell growth and differentiation.
L'invention concerne une nouvelle protéine du type follistatine-3 appartenant à la famille des protéines liées aux inhibines. En particulier, l'invention concerne des molécules d'acides nucléiques isolées qui codent la protéine humaine du type considéré. L'invention concerne également des polypeptides du type follistatine-3, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant d'élaborer lesdits polypeptides. L'invention concerne en outre des procédés de criblage qui permettent d'identifier des agonistes et des antagonistes vis-à-vis de l'activité de la follistatine-3. L'invention concerne enfin des procédés diagnostiques permettant de détecter les troubles liés au système de reproduction et les troubles de la régulation de la croissance et de la différenciation cellulaires, ainsi que des procédés thérapeutiques permettant de traiter ces deux catégories de troubles.
Duan Roxanne
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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