8-carboxamido-2,6-methano-3-benzazocines

Details 8-carboxamido-2,6-methano-3-benzazocines 8-carboxamido-2,6-methano-3-benzazocines

C - Chemistry, Metallurgy

07

D

C07D 221/26 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01) A61P 25/36 (2006.01) C07D 401/04 (2006.01) C07D 405/06 (2006.01) C07D 489/00 (2006.01) C07D 489/08 (2006.01) C07D 489/10 (2006.01) C07D 491/20 (2006.01) C07D 491/22 (2006.01)

Patent

CA 2426942

8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is - CH2-OH, -CH2NH2, -NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.

L'invention porte sur des 2,6-méthano-3-benzazocines substitués en position 8, de structure générale I dans laquelle A représente un groupement CH¿2?-OH, -CH¿2?NH¿2?, -NHSO¿2?CH¿3?, et Y représente par un atome d'O, S ou un groupe NOH. Ces composés sont utiles en tant qu'analgésiques, qu'agents antidiarrhéïques, et en tant que médicaments contre les convulsions, la toux, et contre la dépendance aux drogues. Les 8-carboxamides, les thiocarboxamides, les hydroxyamidines et les formamides sont préférés.

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