Injection system for gene delivery

Details Injection system for gene delivery Injection system for gene delivery

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61B 8/00 (2006.01) A61B 8/08 (2006.01) A61B 8/12 (2006.01) A61B 17/22 (2006.01) A61K 49/22 (2006.01) A61M 5/178 (2006.01) A61M 25/095 (2006.01) A61B 17/00 (2006.01) A61B 19/00 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2312142

An injection catheter is provided with a piezoelectric ultrasound emitting device at its distal end, capable of emitting ultrasound of different energy levels. It can be used to image the location of penetration of an internal organ of a patient by the catheter needle, by supply of echocontrast material through the needle and analysis of the ultrasound reflections therefrom. It can also be used to cause tissue perturbation or disruption at the imaged location, e.g. to initiate tissue angiogenesis, by choice of suitable ultrasound energy level of emission, and for delivery of therapeutic substances such as DNA to the disrupted tissue, for better uptake in gene therapy.

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