Indoleamine 2,3-dioxygenase (ido) inhibitors

Details Indoleamine 2,3-dioxygenase (ido) inhibitors Indoleamine 2,3-dioxygenase (ido) inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/5415 (2006.01) C07C 49/713 (2006.01) C07D 279/14 (2006.01) C07D 279/16 (2006.01) C07D 307/77 (2006.01) C07D 307/87 (2006.01) C07D 311/06 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2581674

Inhibitors of indoleamine 2,3-dioxygenase (IDO) are provided as are pharmaceutical compositions containing such inhibitors as well as the use of such inhibitors and compositions for the treatment of a condition in a mammalian subject characterized by pathology of the IDO-mediated tryptophan metabolic pathway. Such conditions may involve suppression of T-cell mediated immune response or may directly result from depletion of tryptophan or accumulation of a product of tryptophan degradation. Specific disease conditions include cataracts, age-related yellowing in the eye, neurodegenerative disorders, mood disorders, cancer and various bacteria/viral infections. IDO inhibitors of this invention are substituted naphthalene and anthracene diones. Novel compounds of this invention include the following taurine-substituted naphthaquinone structure.

L'invention porte sur un système des inhibiteurs de la indoléamine 2,3-dioxygénase (IDO), sur des préparations pharmaceutiques les contenant, sur l'utilisation de ces inhibiteurs et préparations pour le traitement d'états de mammifères souffrant d'une pathologie de la voie du métabolisme du tryptophane médiée par l'IDO. Ces états peuvent conduire à la suppression de la réponse immunitaire médiée par les cellules T ou peuvent directement résulter de l'appauvrissement en tryptophane ou de l'accumulation d'un produit de dégradation du tryptophane. Les troubles spécifiques en question comprennent: la cataracte, le jaunissement de l'oeil du à l'âge, des troubles neurodégénératifs, des troubles de l'humeur, le cancer et différentes infections bactériennes ou virales. Les inhibiteurs de l'IDO de l'invention sont des naphthalène-dione et anthracène-dione substituées. Les nouveaux composés de l'invention comprennent la structure de formule suivante (VI) de naphthaquinone à substitution de taurine.

Affiliated with

Also associated with

Rating

Indoleamine 2,3-dioxygenase (ido) inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indoleamine 2,3-dioxygenase (ido) inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indoleamine 2,3-dioxygenase (ido) inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1810635