Methods and compositions for detecting hepatitis e virus

G - Physics – 01 – N

Patent

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Details

G01N 33/576 (2006.01) A61K 39/29 (2006.01) C07K 14/08 (2006.01) C07K 16/10 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2306451

Disclosed herein are methods and compositions for detecting the presence in a sample of a US-type or a US-subtype hepatitis E virus, including naturally occurring variants thereof. In particular, the invention provides nucleic acid sequences corresponding to the genome of the US-type or US-subtype hepatitis E virus, amino acid sequences, including epitope sequences, encoded by the genomes of such viruses, and antibodies that bind specifically to such amino acid sequences. The invention further provides methods and compositions for immunizing individuals against infection by, or for treating individuals already infected with such a virus.

Cette invention se rapporte à des procédés et à des compositions permettant de détecter la présence dans un échantillon d'un virus de l'hépatite E du type US ou du sous-type US, y compris des variants de ce virus existant à l'état naturel. Cette invention se rapporte en particulier à des séquences d'acides nucléiques correspondant au génome du virus de l'hépatite E du type US ou du sous-type US, à des séquences d'acides aminés, y compris des séquences d'épitopes, codées par les génomes de tels virus, et à des anticorps qui se fixent spécifiquement à ces séquences d'acides aminés. Cette invention se rapporte en outre à des procédés et à des compositions servant à immuniser des individus contre l'infection par ce virus ou à traiter des individus déjà infectés par ce virus.

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