C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2690865
The invention relates to methods of determining an appropriate cancer therapy for a subject based on intratumoral expression levels of Ribonucleotide Reductase Ml (RRM1) and thymidylate synthase (TS) gene expression, as well as to methods of predicting clinical outcome (prognosis) based on cytoplasmic levels of TS protein. Compositions and kits useful for the methods are also provided.
L'invention concerne des procédés de détermination d'une thérapie du cancer appropriée pour un sujet sur la base des niveaux d'expression intratumoraux de la ribonucléotide réductase M1 (RRM1) et de l'expression du gène de la thymidylate synthase (TS), ainsi que des procédés de prédiction du résultat clinique (pronostic) sur la base des niveaux cytoplasmiques de la protéine TS. Des compositions et des kits utiles pour les procédés sont également fournis.
Gowling Lafleur Henderson Llp
University Of South Florida
LandOfFree
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