Modified nucleosides for the treatment of viral infections...

Details Modified nucleosides for the treatment of viral infections... Modified nucleosides for the treatment of viral infections...

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61K 31/7068 (2006.01) A61K 31/7084 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2743451

The disclosed invention is a composition for and a method of treating a Flaviviridae (including BVDB and HCV), Orthornyxoviridae (including Influenza A and B) or Paratnyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction ("TR-PCR'). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.

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