Process for the preparation of galanthamine and its derivatives

Details Process for the preparation of galanthamine and its derivatives Process for the preparation of galanthamine and its derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/06 (2006.01) C07D 491/10 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2230824

A process for preparing a compound having a formula (4) or (5), in either optically-enriched or racemic form, wherein R1, R2, R3 and R4 are independently selected from hydrogen, alkyl, aryl, alkaryl, aralkyl and acyl groups, comprises mixing with a plant extract an oxidative cyclisation precursor of the said compound.

Cette invention concerne un procédé de préparation d'un composé représenté par la formule (4) ou (5), qui présente soit une forme racémique soit une forme à activité optique renforcée. Dans cette formule R<1>, R<2>, R<3> et R<4> sont sélectionnés indépendamment parmi l'hydrogène et des groupes alkyle, aryle, alkaryle, aralkyle et acyle. Ledit procédé consiste à mélanger à un extrait végétal un précurseur de cyclisation oxydante dudit composé.

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