Medicinal preparations for treating sex hormone-dependent...

A - Human Necessities – 61 – K

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Details

A61K 45/06 (2006.01) A61K 31/519 (2006.01) A61K 38/08 (2006.01) A61K 38/09 (2006.01) A61P 5/24 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2412899

Medicinal preparations for treating sex hormone--dependent diseases which comprise a combination of a compound having a luteinizing hormone-releasing hormone agonistic effect or its salt with a compound having a luteinizing hormone-releasing hormone antagonistic effect or its salt for administering the compound having a luteinizing hormone-releasing hormone agonistic effect or its salt followed by the compound having a luteinizing hormone-releasing hormone antagonistic effect or its salt. By using these preparations, the concentration of a sex hormone (for example, testosterone, LH, FSH, estrogen) can be quickly recovered after the medicable period of a compound having a luteinizing hormone-releasing hormone antagonistic effect or its salt or a preparation containing the same (preferably a sustained-release preparation), which makes it possible to definitely determine the drug cessation period in an intermittent treatment.

L'invention porte sur des préparations médicinales destinées à traiter des maladies dépendant des hormones sexuelles et comprenant une combinaison d'un composé ayant un effet de la lutéolibérine ou de son sel avec un composé ayant un antagonisme de la lutéolibérine ou son sel. Avec ces préparations, la concentration d'une hormone sexuelle (telle que la testostérone, LH, FSH, l'oestrogène) peut être rapidement récupérée après la période de médication d'un composé ayant un antagonisme de la lutéolibérine ou son sel ou une préparation contenant celui-ci (de préférence une préparation à libération prolongée), ce qui permet de déterminer rapidement la période de repos médicamenteuse au cours d'un traitement intermittent.

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