Detection of cardiovascular lesions

A - Human Necessities – 61 – K

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A61K 51/10 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2107567

This invention relates to reagents and methods for detecting and imaging cardiovascular lesions such as atherosclerotic plaques, vascular clots including thrombi and emboli, myocardial infarction, and other organ infarcts. Monospecific antibody imaging agent conjugates specific for one type of leukocyte, as well as multispecific antibody imaging agent conjugates specific for at least one type of leukocyte and for antigens associated with fibrin, myosin or platelets, are used in the present invention. Multispecific antibody imaging agent conjugates specific for at least two different antigens selected from the group consisting of fibrin-, myosin- and platelet associated antigens are also provided.

L'invention porte sur des réactifs et autres moyens de dépistage et de visualisation des lésions cardiovasculaires telles que l'athérosclérose, caillots sanguins tels que thrombus et emboles, l'infactus du myocarde et les infarctus d'autres organes. Des conjugués d'agents de visualisation d'anticorps monospécifiques propres à un type de leucocyte ainsi que des conjugués d'agents de visualisation d'anticorps multispécifiques propres à au moins un autre type de leucocyte et à des antigènes associés à la fibrine, à la myosine ou aux plaquettes, sont mis en oeuvre dans le cadre de la présente invention. La présente invention porte également sur des conjugués d'agents de visualisation d'anticorps multispécifiques propres à au moins deux antigènes différents choisis parmi le groupe constitué d'antigènes associés à la fibrine, à la myosine et à des plaquettes.

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