C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2716856
The present invention relates to chemical compounds having a general formula (I) wherein A1-5 and 7-8, D', L1, L2, R1, R3, R6-8, n and o are defined herein, and synthetic intermediates, which are capable of modulating the activity of Aurora kinase proteins and, thereby, influencing various disease states and conditions related to the activities of Aurora kinases. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related dis-eases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
La présente invention concerne des composés chimiques répondant à la formule générale (I) dans laquelle A1-5 et 7-8, D', L1, L2, R1, R3, R6-8, n et o sont définis dans la description, et des intermédiaires synthétiques, qui sont capables de moduler lactivité des protéines Aurora kinases et, de ce fait, dinfluencer divers états pathologiques et diverses conditions associés aux activités des Aurora kinases. Par exemple, les composés peuvent influencer le processus du cycle cellulaire et de la prolifération cellulaire pour traiter le cancer et les maladies liées au cancer. Linvention comprend également des compositions pharmaceutiques, incluant les composés, et les procédés de traitement des états pathologiques associés à lactivité de lAurora kinase.
Human Jason B.
White Ryan
Amgen Inc.
Gowling Lafleur Henderson Llp
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