A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/19 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2744035
Provided are methods to induce and maintain a protective cytotoxic T- lymphocyte response to a peptide of the HER/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including patients having low to intermediate levels of HER2/neu expression. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. Also provided are vaccine compositions for use in the methods.
La présente invention concerne des procédés pour induire et maintenir une réponse de lymphocytes T cytotoxiques protectrice à un peptide de loncogène ?ER/neu, GP2, ayant pour effet dinduire et maintenir une immunité protectrice ou thérapeutique contre le cancer du sein chez une patiente en rémission clinique, comprenant des patientes ayant des taux faibles à intermédiaires dexpression de HER2/neu. Les procédés comprennent ladministration à la patiente dune quantité efficace dune composition de vaccin comprenant un véhicule pharmaceutiquement acceptable, un adjuvant tel que GM-CSF, et le peptide GP2. Les procédés peuvent comprendre en outre ladministration dune dose de vaccin de rappel périodique comme requis en raison dune diminution de limmunité de lymphocytes T spécifique à GP2. La présente invention concerne en outre des compositions de vaccin pour utilisation dans les procédés.
Peoples George
Ponniah Sathibalan
Kirby Eades Gale Baker
The Henry M. Jackson Foundation For The Advancement Of Military Inc.
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