Substituted 3-aminosydnone imines, processes for their...

Details Substituted 3-aminosydnone imines, processes for their... Substituted 3-aminosydnone imines, processes for their...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/54 (2006.01) C07D 271/04 (2006.01)

Patent

CA 2042321

23233-251 ABSTRACT Novel substituted 3-aminosydnone imines of the formula I Image (I) and their pharmacologically acceptable acid addition salts, in which A denotes the radical -SO-, R1 denotes the radical -COR2 or hydrogen, R2 denotes (C1 to C4)alkyl, (C1 to C4)alkoxy-(C1 to C4)alkyl, (C1 to C4)alkoxy, (C5 to C7)cycloalkyl, phenyl or a phenyl radical which is mono- to trisubstituted by radicals selected from the group consisting of halogen atoms, (C1 to C4) radicals and (C1 to C4)alkoxy radicals and processes for preparing thereof. The compounds have useful pharmacological properties, such as haemodynamic, thrombocyte function-inhibiting and anti- thrombotic properties and have a longer duration of action than similar compounds known in the prior art. They also lower the blood pressure as well as the pulmonary artery pressure and the left ventricular end-diastolic pressure, contributing to a relief of the load on the heart without provoking tachycardia at the same time.

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