Thrombin-cleavable chimeric proteins

Details Thrombin-cleavable chimeric proteins Thrombin-cleavable chimeric proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) C07H 21/00 (2006.01) C07K 14/745 (2006.01) C07K 14/75 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 9/74 (2006.01) C12N 15/12 (2006.01) C12N 15/57 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2463772

The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.

L'invention concerne des protéines chimériques comprenant une séquence artificielle destinée au clivage par la thrombine, dans lesquelles le peptide d'activation est le fibrinopeptide A. De préférence, lesdites protéines chimériques sont dérivées de la proenzyme d'une sérine protéase, telle que la protéine C (PC) ou le facteur humain X (FX), par le biais du remplacement du peptide d'activation de cette proenzyme par le fibrinopeptide A ou une portion correspondante renfermant au moins deux acides aminés P¿10? à P¿1? dudit fibrinopeptide.

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