Substituted heterocycles and their use as allosteric...

Details Substituted heterocycles and their use as allosteric... Substituted heterocycles and their use as allosteric...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61P 25/00 (2006.01) C07D 403/02 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2754180

The present invention is related to heterocycles represented by a compound of Formula (I) that are novel allosteric modulators of .alpha.7 nAChRs and/or GABA A receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on .alpha.7 nAChRs and negative allosteric modulation of GABA A receptors in a mammal by administering an effective amount of a compound of Formula (I).

Cette invention concerne des hétérocycles représentés par un composé de formule (I) constituant de nouveaux modulateurs allostériques des récepteurs a7 nAChR et/ou des récepteurs GABA-A. L'invention concerne également le traitement de maladies qui sont sensibles à la stimulation de l'action de l'acétylcholine sur les récepteurs a7 nAChR et la modulation allostérique négative des récepteurs GABA-A chez le mammifère par administration d'une quantité efficace d'un composé de formule (I).

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