C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4706 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61P 37/06 (2006.01) C07D 215/42 (2006.01) C07D 239/72 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2665819
Small molecule compounds and compositions containing said compounds useful for inhibiting signaling by certain Toll-like receptors (TLRs), particularly TLR9, are provided. The compounds and compositions can be used to inhibit immune responses, including unwanted immune responses in particular. Compounds, compositions, and methods are provided to treat a variety of conditions involving unwanted immune responses, including for example autoimmune disease, inflammation, transplant rejection, and sepsis.
L'invention concerne des composés à petites molécules et des compositions contenant ces composés, utiles pour inhiber la signalisation par certains récepteurs de type Toll (TLR), en particulier TLR9. Ces composés et ces compositions peuvent être utilisés pour inhiber des réactions immunitaires, y compris des réactions immunitaires indésirables en particulier. L'invention concerne plus précisément des composés, des compositions et des méthodes destinés au traitement de divers troubles impliquant des réactions immunitaires indésirables, y compris des maladies auto-immunes, l'inflammation, le rejet de greffon et la sepsie.
Lipford Grayson B.
Nguyen Toan B.
Zepp Charles M.
Coley Pharmaceutical Group Inc.
Torys Llp
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