Method of promoting keratinocyte proliferation

Details Method of promoting keratinocyte proliferation Method of promoting keratinocyte proliferation

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 38/18 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2321168

The present invention provides methods, improved cell culture medium and kits for promoting epithelial stem cell and keratinocyte proliferation and differentiation by growth in the presence of angiotensinogen, AI, AI analogues, and/or AI fragments and analogues thereof, AII analogues, AII fragments or analogues thereof, AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.

L'invention concerne des procédés, des milieux de culture cellulaire améliorés et des ensembles de matériel permettant d'activer la prolifération et la différentiation des cellules souche épithéliales et des kératinocytes par une croissance effectuée en présence d'antgiotensinogènes, d'AI, d'analogues d'AI et/ou de fragments d'AI et d'analogues de ces derniers, d'analogues d'AII, de fragments ou d'analogues d'AII, d'agonistes de récepteurs d'AII AT¿2? de type 2, utilisés seuls ou combinés à d'autres facteurs de croissance et cytokines.

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