Method evolved for recognition of thrombophilia (mert)

Details Method evolved for recognition of thrombophilia (mert) Method evolved for recognition of thrombophilia (mert)

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2553545

Methods for predicting an individual~s genetic risk for developing venous thrombosis in diverse ethnic populations is disclosed, as are arrays and kits which can be used to practice the method. The method includes screening for mutations, polymorphisms, or both, in at least eight venous thrombosis-related molecules, such as antithrombin III, protein C, protein S, fibrinogen, factor V, prothrombin (factor II), methylenetetrahydrofolate reductase (MTHFR), and angiotensin I-converting enzyme (ACE) molecules which are associated with venous thrombosis.

L'invention porte sur des procédés permettant de prévoir les prédispositions génétiques à la thrombose veineuse d'individus dans diverses populations ethniques, ainsi que sur des jeux d'échantillon et des trousses ou coffrets permettant de réaliser ce procédé. Le procédé consiste à dépister les mutations et/ou les polymorphismes dans au moins huit molécules associées à la thrombose veineuse, telles que les molécules d'antithrombine III, de protéine C, de protéine S, de fibrinogène, de facteur V, de prothrombine (facteur II), de méthylènetétrahydrofolate réductase (MTHFR), et d'enzyme de conversion de l'angiotensine de type I (ACE).

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