C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2441925
Short peptides are provided, which bind to a body fluid sample obtained from a schizophrenic patient at a substantively higher level than to a body fluid sample obtained from a non-schizophrenic individual. The peptides are no more than 10 amino acids long and comprise a continuous sequence of at least 5 amino acids which consists of at least one positively charged amino acid at one of its ends. The provided peptides, which are the putative binding sites of autoantibodies found in high levels in schizophrenic individuals, are thus useful in diagnosis of schizophrenia.
L'invention concerne des peptides courts se fixant sur un échantillon de liquide organique prélevé chez un patient schizophrène en quantité sensiblement supérieure qu'un échantillon de liquide organique prélevé chez un patient non-schizophrène. Les peptides présentent une longueur égale ou inférieure à 10 acides aminés et comprennent une séquence continue d'au moins 5 acides aminés, laquelle séquence comprend au moins un acide aminé positivement chargé à l'une de ses extrémités. Les peptides décrits dans cette invention, qui sont d'éventuels sites de liaison d'autoanticorps présents en grand nombre chez des patients schizophrènes, sont utiles pour le diagnostic de la schizophrénie.
Ltd. Yeda Research And Development Co.
Smart & Biggar
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