Methods of using death receptor ligands and cd20 antibodies

Details Methods of using death receptor ligands and cd20 antibodies Methods of using death receptor ligands and cd20 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2577828

Methods for using death receptor ligands, such as Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and CD20 antibodies to treat conditions such as cancer and immune related diseases are provided. Embodiments of the invention include methods of using Apo2L/TRAIL or death receptor antibodies such as DR5 antibodies and DR4 antibodies in combination with CD20 antibodies.

L'invention concerne des méthodes d'utilisation de ligands de récepteurs de mort, tels que des polypeptides ligands Apo-2/TRAIL ou anticorps de récepteurs de mort, ainsi que d'anticorps CD20 afin de traiter des états tels que le cancer et les maladies liées au système immunitaire. Dans des modes de réalisation, l'invention concerne des méthodes d'utilisation d'Apo2L/TRAIL ou anticorps de récepteurs de mort tels que des anticorps des récepteurs DR5 et des anticorps des récepteurs DR4 en combinaison avec des anticorps CD20.

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