C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/18 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 19/00 (2006.01) A61P 37/00 (2006.01) C07D 271/12 (2006.01) C07D 285/14 (2006.01) C07D 333/60 (2006.01)
Patent
CA 2552433
E-cinnamic amides of piperazine derivatives according to formula (I) wherein X is chloro or Fluor and R1 is an aromatic or heteroaromatic group. Their pharmaceutically acceptable salts, pharmaceutical compositions containing them and their use in therapy for treating inflammatory, autoimmune, proliferative or hyperproliferative diseases.
L'invention concerne des amides <I>E</I>-cinnamiques de dérivés pipérazinés représentés par la formule générale (I) dans laquelle X désigne un groupe chloro ou fluoro et R?1¿ désigne un groupe aromatique ou hétéroaromatique. L'invention concerne également des sels de qualité pharmaceutique de ces amides cinnamiques, des compositions pharmaceutiques contenant ces amides cinnamiques et leur application en thérapie pour le traitement de maladies inflammatoires, auto-immunes, prolifératives ou hyperprolifératives.
Berg Helena
Wellner Eric
Active Biotech Ab
Smart & Biggar
LandOfFree
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