Monoclonal antibodies against activated protein c

Details Monoclonal antibodies against activated protein c Monoclonal antibodies against activated protein c

C - Chemistry, Metallurgy

07

K

C07K 16/36 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2703738

The present invention provides monoclonal antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Other antibodies inhibit both activated protein C and activation of unactivated protein C. Methods of treatment employing these antibodies are described herein as are methods of screening for and detecting these antibodies.

La présente invention concerne des anticorps monoclonaux qui se lient sélectivement et inhibent la protéine C activée sans se lier à la protéine C inactivée ou l'inhiber. D'autres anticorps inhibent à la fois la protéine C activée et l'activation de la protéine C inactivée. Les procédés de traitement utilisant ces anticorps sont décrits ici, ainsi que des procédés de criblage et de détection de ces anticorps.

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