C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/66 (2006.01) A61K 38/46 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2707051
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
La présente invention porte sur des procédés pour la fabrication, la purification, la formulation et l'utilisation de protéines élastases recombinantes biologiquement actives. L'invention porte sur des procédés recombinants pour la fabrication de protéines élastases thérapeutiquement utiles, ainsi que sur des compositions pharmaceutiques comprenant lesdites protéines élastases. De nouvelles protéines et préparations de protéines élastases recombinantes sont également décrites. L'invention porte sur des procédés pour le traitement et la prévention de maladies de conduits biologiques à l'aide de compositions pharmaceutiques contenant les protéines élastases de l'invention.
Bland Kimberly
Ding Bee C.
Franano F. Nicholas
Wong Marco D.
Proteon Therapeutics Inc.
Torys Llp
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