Substituted piperazine derivatives, the preparation thereof...

Details Substituted piperazine derivatives, the preparation thereof... Substituted piperazine derivatives, the preparation thereof...

C - Chemistry, Metallurgy

07

D

C07D 295/14 (2006.01) A61K 31/495 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 295/145 (2006.01)

Patent

CA 2388759

The present invention relates to substituted piperazine derivatives of general formula Image wherein R a, R b, R c R f, R g and m, n and X are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

La présente invention concerne des dérivés de pipérazine substitués, de formule générale (I), dans laquelle Ra, Rb, Rc, Rf, Rg, ainsi que m, n et X possèdent la signification de la revendication 1, les isomères et les sels de ces dérivés, en particulier leurs sels physiologiquement acceptables, représentant des inhibiteurs précieux de la protéine de transfert de triglycérides microsomale (MTP), des produits pharmaceutiques contenant ces composés, leur utilisation, ainsi que leur fabrication.

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