Lipid rafts and clostridial toxins

Details Lipid rafts and clostridial toxins Lipid rafts and clostridial toxins

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2549432

The present invention is directed to methods of altering the degree of internalization of a Clostridial toxin; methods of preventing or treating botulinum toxin intoxication; methods of treating metabolic disorders, muscular disorders, nervous system disorders, and/or pain conditions; methods of inhibiting the formation of lipid rafts on cell membranes; methods of treating a disease associated with lipid rafts; and methods of identifying a compound that alters the internalization of a Clostridial toxin.

L'invention concerne des méthodes d'altération du degré d'internalisation d'une toxine clostridienne ; des méthodes de prévention ou de traitement d'une infection par une toxine botulinique ; des méthodes de traitement de troubles métaboliques, de troubles musculaires, de troubles du système nerveux, et/ou de douleurs ; des méthodes d'inhibition de formation de radeaux lipidiques sur des membranes cellulaires ; des méthodes de traitement d'une maladie associée à des radeaux lipidiques ; et des méthodes d'identification d'un composé qui altère l'internalisation d'une toxine clostridienne.

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