Muc-1 as an immunosuppressive therapeutic agent for the...

Details Muc-1 as an immunosuppressive therapeutic agent for the... Muc-1 as an immunosuppressive therapeutic agent for the...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2264748

The invention relates to novel methods of treatment and pharmaceutical compositions comprising the mucin MUC-1 and its derivatives. Preferred MUC-1 derivatives comprise multiple tandem repeats of the MUC-1 core sequence. In fact, the figure shows that lower serum MUC-1 levels correlate with longer survival time. The disclosed compositions and methods are particularly useful in treating autoimmune disorders, inflammatory disorders, organ transplant rejection and graft versus host disease.

L'invention porte sur de nouveaux modes de traitement et de nouvelles préparations pharmaceutiques à base de mucine MUC-1 et de ses dérivés. Les dérivés préférés comportent de multiples unités répétées en tandem de la séquence coeur du MUC-1. La figure montre que de faibles taux sériques de MUC-1 sont en relation avec une survie plus longue. Les préparations pharmaceutiques et procédés de l'invention sont particulièrement intéressants pour traiter les troubles de nature auto-immunitaire et inflammatoires, le rejet des greffes et les problèmes greffon/organisme récepteur.

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