C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4162 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2742783
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
La présente invention concerne de nouveaux aminotétrahydropyranes substitués de formule structurale I qui sont des inhibiteurs de lenzyme dipeptidyle peptidase-IV et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles lenzyme dipeptidyle peptidase-IV est impliquée, telles que le diabète et particulièrement le diabète de type 2. Linvention concerne en outre des compositions pharmaceutiques comprenant ces composés et lutilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles lenzyme dipeptidyle peptidase-IV est impliquée.
Biftu Tesfaye
Chen Ping
Cox Jason M.
Weber Ann E.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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