Pharmaceutically active compounds and methods of use thereof

Details Pharmaceutically active compounds and methods of use thereof Pharmaceutically active compounds and methods of use thereof

C - Chemistry, Metallurgy

07

C

C07C 237/26 (2006.01) A61K 31/65 (2006.01) C07C 255/43 (2006.01) C07D 295/155 (2006.01)

Patent

CA 2318580

The invention includes new substituted tetracycline-type compounds that exhibit significant antibacterial activity, including against both gram- positive and gram-negative bacteria. It has been found that compounds of the invention are highly active against both gram positive and gram negative tetracycline sensitive and tetracycline resistant bacteria.

L'invention se rapporte à de nouveaux composés substitués de type tétracycline qui présentent une forte activité antibactérienne, dirigée notamment contre les bactéries à la fois gram-positives et gram-négatives. Ces composés s'avèrent être très actifs contre à la fois les bactéries gram-positives et gram-négatives sensibles à la tétracycline et résistantes à la tétracycline.

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