Sphingomyelinase enzymes and uses relating thereto

Details Sphingomyelinase enzymes and uses relating thereto Sphingomyelinase enzymes and uses relating thereto

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/17 (2006.01) C07K 16/40 (2006.01) C12N 15/55 (2006.01) C12Q 1/34 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2440679

Two novel sphingomyelinases are provided, having optimum activities at pH7 and pH8, respectively. The two proteins have different tissue sources, the pH7 form from e.g. T cell lymphomas, and the pH8 form from e.g. B cell lymphomas. Methods of treatment and diagnosis, fragments, antibodies, nucleic acids and pharmaceutical compositions are also provided.

La présente invention concerne deux nouvelles sphingomyélinases, dont les activités optimums respectives sont à un pH 7 et à un pH 8. Ces deux protéines ont des sources tissulaires différentes, la forme du pH 7 provenant, par exemple de lymphomes de lymphocytes T, et la forme du pH 8 provenant, par exemple de lymphomes de cellules B. Cette invention concerne aussi des techniques de traitement et de diagnostic, des fragments, des anticorps, des acides nucléiques et des compositions pharmaceutiques.

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