Heterocyclic compounds as ligands of the gabaa receptor

Details Heterocyclic compounds as ligands of the gabaa receptor Heterocyclic compounds as ligands of the gabaa receptor

C - Chemistry, Metallurgy

07

D

C07D 491/14 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2420967

Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.

Cette invention concerne des composés hétérocycliques de formule (I) et des sels harmaceutiquement acceptables de ces composés dans lesquels les variables A, V, Y, J, E, X, G, Q, W, Z, b, n et m sont comme définis dans le descriptif. Ces composés sont des agonistes, des antagonistes ou des agonistes inverses hautement sélectifs des récepteurs cérébraux GABA¿A? cerveau ou des promédicaments desdits agonistes, antagonistes ou agonistes inverses du récepteur cérébral GABA¿A?.

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