Novel pyrazolo [1,5-a]pyridine derivatives and their use as...

Details Novel pyrazolo [1,5-a]pyridine derivatives and their use as... Novel pyrazolo [1,5-a]pyridine derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 237/00 (2006.01)

Patent

CA 2478715

The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula (I), that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.

L'invention concerne des nouveaux dérivés de pyrazolo[1,5-a]pyridine représentés par la formule générale (I), lesquels se lient avec une grande affinité aux récepteurs CRF¿1?, y compris aux récepteurs CRF¿1? humains. La présente invention concerne également des méthodes permettant d'utiliser ces composés pour traiter un trouble ou une affection pour lesquels le traitement peut être réalisé ou facilité par antagonisation d'un récepteur CRF, tels que les maladies ou les troubles du système nerveux central, en particulier, l'anxiété, et les troubles liés à la dépression et au stress..

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