C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/228
C07H 17/00 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2018710
7513P/5304A 6/13/89:Fl 17909 TITLE OF THE INVENTION NEW L-683,590 MICROBIAL TRANSFORMATION PRODUCT ABSTRACT OF THE DISCLOSURE Described is a new L-679,934 (FK-506) antagonist, L-686,292, a C-15, C-31 bisdemethylated, derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide reverses the immunosuppressant action of L-679,934 (FK-506), and can be used diagnostically as a tool to determine the presence of FK-506 macrolide type immunosuppressants in natural product broths, distinguishing such immunosuppressants from other chemical families such as the cyclosporins.
Arison Byron H.
Chen Shieh-Shung T.
Wicker Linda S.
Arison Byron H.
Chen Shieh-Shung T.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Wicker Linda S.
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