Polypeptide analogs of apolipoprotein e, diagnostic systems...

Details Polypeptide analogs of apolipoprotein e, diagnostic systems... Polypeptide analogs of apolipoprotein e, diagnostic systems...

C - Chemistry, Metallurgy

07

K

530/13, 167/139,

C07K 14/775 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2023521

ABSTRACT The present invention contemplates a multimeric polypeptide capable of mimicking the ability of apo E to induce differeniated cellular function. The repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRKLRKRLLRDADDL. Also contemplated is a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of the polypeptide. Described as well, is the use of the polypeptide in preparing diagnostic antibodies, and their use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.

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