Nanoscale neuromodulating platform for retina neuron...

G - Physics – 01 – N

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G01N 33/53 (2006.01) C12M 1/42 (2006.01) C12N 5/0793 (2010.01)

Patent

CA 2606402

Postsynaptic membrance receptor proteins of retinal neurons proximal to the rods and cones mediate the transmission of visual signals at multiple types of chemical synapses in the normally functioning retina, and there is reason to believe that these proximal retinal neurons in certain cases remain functional despite the disease-induced loss of rod and cone visual signaling. The invention is a nanoscale molecular structure that can selectively attach to the extracellular face of specific membrane receptors of post-photoreceptor retinal neurons and, by modulating the postsynaptic receptor's activity in response to light, restore visual signaling in retina damaged by photoreceptor degenerative disease.

Selon l'invention, des protéines réceptrices de la membrane postsynaptique de neurones rétiniens proximaux des cônes et bâtonnets médient la transmission des signaux visuels au niveau de plusieurs types de synapses chimiques dans la rétine fonctionnant normalement. Il y a des raisons de croire que, dans certains cas, ces neurones rétiniens proximaux restent fonctionnels malgré la perte induite par une maladie de la signalisation visuelle des cônes et des bâtonnets. L'invention concerne une structure moléculaire nanométrique qui se fixe sélectivement à la surface extracellulaire de récepteurs membranaires spécifiques des neurones rétiniens post-photorécepteurs et, en modulant l'activité des récepteurs postsynaptiques en réaction à la lumière, rétablit la signalisation visuelle dans un rétine endommagée par une maladie dégénérative des photorécepteurs.

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