Therapeutic vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61P 25/28 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2633399

The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis. In particular, the present invention provides methods and compositions for eliciting a highly specific and highly effective immune response in an organism, but particularly within an animal, particularly a mammal or a human, which is capable of preventing or alleviating amyloidosis, or the symptoms associated with amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer' s Disease (AD) , including diseases or conditions characterized by a loss of cognitive memory capacity such as, for example, mild cognitive impairment (MCI).

La présente invention concerne des procédés et des compositions d'utilisation thérapeutique et diagnostique dans le traitement de maladies et de troubles causés par des protéines amyloïde ou de type amyloïde ou associés à ces protéines, notamment l'amylose. Cette invention concerne en particulier de nouveaux procédés et de nouvelles compositions permettant d'éliciter une réponse immunitaire hautement spécifique et hautement sélective dans un organisme, mais plus particulièrement chez un mammifère ou chez un humain, qui est capable de prévenir ou d'atténuer l'amylose, ou les symptômes associés à l'amylose, un groupe de maladies et de troubles associés à la formation de plaque d'amyloïdes notamment l'amylose secondaire et l'amylose liée à l'âge, notamment des troubles neurologiques tels que la maladie d'Alzheimer (AD), notamment des maladies ou des pathologies caractérisées par une perte de capacité de mémoire cognitive, telles que par exemple la déficience intellectuelle légère (MCI).

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