A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/12 (2006.01)
Patent
CA 2633472
The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux- enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
L'invention concerne des formulations adhésives pouvant se solidifier, des procédés pour administrer des médicaments, et des couches solidifiées destinées à être administrer par voie cutanée. La formulation peut comprendre un médicament, un excipient de solvants, et un agent de solidification. L'excipient de solvants peut comprendre un système de solvants volatiles comprenant au moins un solvant volatile, et un système de solvants non volatiles comportant au moins un solvant non volatile, ce dernier étant un solvant non volatile, fluidifiant, facilitant l'administration de médicaments dans des quantités thérapeutiquement efficaces sur une période soutenue. La formulation peut présenter une viscosité permettant son application à la surface de la peau, avant l'évaporation du système de solvants. Lorsqu'elle est appliquée sur la peau, la formulation peut former une couche solidifiée après l'évaporation d'au moins une partie du système de solvants volatiles.
Sharma Sanjay
Warner Kevin S.
Zhang Jie
Ridout & Maybee Llp
Zars Pharma Inc.
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