3-3-di-substituted-oxindoles as inhibitors of translation...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/34 (2006.01)

Patent

CA 2555812

Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2- Hydroxy~phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.

L'invention concerne des compositions et des procédés d'inhibition de la traduction au moyen de 3-(5-tert-butyl-2-hydroxy-phényl)-3-phényl-1,3-dihydro-indol-2-one et/ou de ses dérivés. L'invention concerne également des compositions, des méthodes et des kits de traitement (1) des troubles prolifératifs cellulaires, (2) des troubles dégénératifs non prolifératifs, des troubles dégénératifs, (3) des infections virales et/ou (4) des troubles liés aux infections virales, au moyen de 3-(5-tert-butyl-2-hydroxy-phényl)-3-phényl-1,3-dihydro-indol-2-one et/ou de ses dérivés.

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