N-substituted aminoalkanediphosphonic acids

Details N-substituted aminoalkanediphosphonic acids N-substituted aminoalkanediphosphonic acids

C - Chemistry, Metallurgy

07

F

167/208, 260/251

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/58 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2011586

4- 17483/+ N-substituted aminoalkanediphosphonic acids Abstract Compounds of the formula I Image (I) in which R1 is an aromatic radical, n is 0, 1, 2 or 3, X is an oxy group, a thio group which can be oxidized or an imino group which is unsubstituted or has aliphatic substitllents, alk and alk2 are identical or different divalent aliphatic radicals, and R2 is hydrogen or a monovalent aliphatic radical and salts thereof have properties which regulate caleium metabolism and can be employed for the treatment of diseases connected with disturbances in this metabolism. They are prepared, for example, by reacting a eompound of the formula Image (V), in which X3 is carboxyl with a phosphorylating agent and hydrolysing the primaryproduct.

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