Mutants of human chondromodulin-i (hchm-i) and uses thereof...

Details Mutants of human chondromodulin-i (hchm-i) and uses thereof... Mutants of human chondromodulin-i (hchm-i) and uses thereof...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2543406

[PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.

Cette invention vise à produire un polypeptide présentant une nouvelle structure et bénéficiant d'une activité inhibitrice de l'angiogenèse ou d'une activité inhibitrice de l'ostéoclastogenèse et à produire une protéine recombinante au moyen de l'élaboration d'un procédé de purification de la protéine susmentionnée. Cette invention vise également à produire un ingrédient utilisé pour élaborer des médicaments servant au traitement, notamment, de la tendinite, de la polyarthrite rhumatoïde, de la polyarthrite déformante et de la tumeur maligne. Pour ce faire, cette invention utilise une nouvelle protéine-polypeptide soluble.

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