New fusion molecule based on novel taa variant

Details New fusion molecule based on novel taa variant New fusion molecule based on novel taa variant

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 19/00 (2006.01) C12N 9/88 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) C07K 14/535 (2006.01)

Patent

CA 2673560

This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer immunogenic agent(s) (e.g. vaccines and chimeric molecules) that elicit an immune response specifically directed against cancer cells expressing a CAIX antigenic marker. The novel CAIX variant and related compositions are useful in a wide variety of treatment modalities including, but not limited to protein vaccination, DNA vaccination, and adoptive immunotherapy.

L'invention concerne de nouvelles séquences peptidiques et d'acides nucléiques d'anhydrase carbonique (CAIX), ainsi que des méthodes et des compositions associées, y compris des agents immunogènes anticancéreux (par ex., des vaccins et des molécules chimères) qui élicitent une réponse immune spécifiquement dirigée contre des cellules cancéreuses exprimant un marqueur antigénique CAIX. Le nouveau variant CAIX et des compositions associées sont utilisés dans une grande diversité de modalités de traitement, notamment mais non seulement la vaccination protéique, la vaccination avec ADN, et l'immunothérapie adoptive.

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