C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/22 (2006.01) A61K 31/44 (2006.01) A61K 31/451 (2006.01) A61K 31/5375 (2006.01) A61P 29/00 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 211/34 (2006.01) C07D 221/20 (2006.01) C07D 241/04 (2006.01) C07D 277/46 (2006.01) C07D 295/03 (2006.01) C07D 401/08 (2006.01) C07D 413/08 (2006.01) C07D 417/08 (2006.01) C07D 491/08 (2006.01)
Patent
CA 2503713
The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, X, Z and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
La présente invention a trait à des composés de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, X, Z et n sont tels que définis dans la description, utiles en tant que modulateurs de l'activité du récepteur de chimiokine. Ces composés sont notamment utiles en tant que modulateurs du récepteur de chimiokine CCR-2.
Pasternak Alexander
Yang Lihu
Zhou Changyou
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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