Ascorbic acid as an adjuvant in treatment of malignant...

A - Human Necessities – 61 – K

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A61K 31/375 (2006.01) A61K 31/335 (2006.01) A61K 31/40 (2006.01) A61K 31/475 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) A61K 33/24 (2006.01) A61K 38/14 (2006.01)

Patent

CA 2283739

The invention relates to the use of ascorbic acid or one of its salts to produce a medicament which is suitable for parenteral application, contains more than 5 g ascorbic acid or one of its salts and is used as an adjuvant in the treatment of malignant tumors using chemo- or radiotherapy. The invention also includes a combined preparation comprising a) a ready to use medicament which contains ascorbic acid or one of its salts and which is suitable for parenteral application and b) a ready to use medicament which contains a chemotherapeutically active cytostatic agent which is suitable for parenteral application, provided separately in one packaging unit. Said medicaments a) and b) are used in the treatment of malignant tumors using chemo- or radiotherapy and can be administered at the same time, separately or at set intervals as desired.

L'invention concerne l'utilisation de l'acide ascorbique ou d'un de ses sels pour produire un médicament qui soit adapté à une application parentérale, qui contienne plus de 5 g d'acide ascorbique ou d'un de ses sels et qui soit utilisé comme adjuvant dans le traitement de tumeurs par chimiothérapie ou radiothérapie. L'invention concerne également une préparation combinée contenant, séparément dans un emballage: a) un acide ascorbique ou un de ses sels prêt à l'emploi et adapté à une application parentérale et, b) une préparation médicamenteuse prête à l'emploi, adaptée à une application parentérale et contenant un cytostatique à action chimiothérapeutique. Ces deux constituants peuvent être administrés simultanément, séparément ou, de préférence, échelonnés dans le temps dans le cadre du traitement de tumeurs par chimiothérapie ou radiothérapie.

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