A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 9/48 (2006.01) A61K 38/11 (2006.01) A61K 38/23 (2006.01) A61K 38/28 (2006.01) A61K 47/18 (2006.01) A61K 47/28 (2006.01)
Patent
CA 2249744
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine by virtue of an acid-resistant protective vehicle which transports components of the invention through the stomach. The composition includes an absorption enhancer and a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
La biodisponibilité d'agents actifs peptidiques à administrer par voie orale est améliorée par une composition pharmaceutique assurant la libération ciblée de peptides dans l'intestin au moyen d'un véhicule protecteur résistant aux acides, lequel transporte les composants de l'invention à travers l'estomac. La composition comprend un activateur d'absorption et une dose suffisante d'un agent réducteur du pH pour abaisser la valeur de pH intestinale local. Tous les composants sont libérés ensemble dans l'intestin avec le peptide.
Gilligan James P.
Stern William
Mccarthy Tetrault Llp
Unigene Laboratories Inc.
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