Prokineticin polypeptides, related compositions and methods

Details Prokineticin polypeptides, related compositions and methods Prokineticin polypeptides, related compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/84 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2427800

The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.

L'invention concerne des polypeptides isolés stimulant la contraction du muscle lisse gastro-intestinal, qui comprennent des polypeptides de prokinéticine humaine 1 et de prokinéticine humaine 2, des fragments fonctionnels, et des modifications de ceux-ci. L'invention concerne également des méthodes stimulant la contraction du muscle lisse gastro-intestinal chez un mammifère par administration d'une quantité efficace de prokinéticine. L'invention concerne, en outre, des molécules d'acide nucléique codant pour un polypeptide de prokinéticine, et des anticorps qui se lient sélectivement à un polypeptide de prokinéticine. L'invention concerne enfin des méthodes permettant d'identifier un ligand, un agoniste, ou un antagoniste de récepteur de prokinéticine.

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