Sustained-release tablet production process

Details Sustained-release tablet production process Sustained-release tablet production process

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2648667

Disclosed is a method for producing an extended release tablet, which enables to efficiently produce such an extended release tablet having excellent slow release property that is suppressed in initial release of a drug but capable of completing release of the drug after a predetermined time. Specifically disclosed is a method for producing an extended release tablet wherein a mixture, which is composed of a hydroxyalkyl cellulose (A) whose 2% by mass aqueous solution has a viscosity at 20 ~C of 1-50 mPa~s, a hydroxyalkyl cellulose (B) whose 2% by mass aqueous solution has a viscosity at 20 ~C of not less than 100 mPa~s, an active ingredient and an additive, is granulated by dry granulation and then the thus-obtained granules are formed into tablets, or alternatively the mixture is directly formed into tablets.

L'invention concerne une méthode pour produire un comprimé à libération retardée qui permet de produire efficacement un tel comprimé à libération retardée possédant une excellente propriété de libération lente, dont la libération initiale de médicament est supprimée, mais qui est capable d'achever la libération du médicament après une période prédéterminée. L'invention concerne spécifiquement une méthode pour produire un comprimé à libération retardée à partir d'un mélange à base d'hydroxyalkyle cellulose (A) dont 2% par masse de solution aqueuse a une viscosité de 1-50 mPa~s à 20 °C, d'hydroxyalkyle cellulose (B) dont 2% par masse de solution aqueuse a une viscosité minimum de 100 mPa~s à 20 °C, d'un principe actif et d'un additif, granulé par granulation à sec et dont les granules ainsi obtenus sont mis sous forme de comprimés, ou alternativement le mélange est directement mis sous forme de comprimés.

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