Triazoloquinazoline and pyrazolotriazolopyrimidine...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/14 (2006.01) A61K 31/519 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 11/10 (2006.01) A61P 11/14 (2006.01) A61P 17/04 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 35/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2437437

Triazoloquinazoline and pyrazolotriazolopyrimidine derivatives represented by the following general formula (1): (1) wherein R1 and R2 are each as defined in the description; and A represents a pyrazole or benzene ring optionally substituted by the group as cited in the description. These derivatives show an affinity for adenosine A3 receptor and an effect of lowering ocular tension, which makes them useful in preventing or treating glaucoma.

L'invention concerne des dérivés de triazoloquinazoline et de pyrazolotriazolopyrimidine représentés par la formule générale (I), dans laquelle R?1¿ et R?2¿ ont la signification indiquée dans la description ; A représente un noyau pyrazole ou benzène éventuellement substitué par le groupe cité dans la description. Ces dérivés présentent une affinité pour le récepteur de l'adénosine A3 et font baisser la tension oculaire. Ils sont par conséquent utiles pour prévenir et traiter un glaucome.

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