Increasing production of proteins in gram-positive...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/31 (2006.01) C07K 14/32 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 15/74 (2006.01) C12N 15/75 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2296689

The present invention relates to secretion in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis secretion factors SecDF. The present invention also provides improved methods for the secretion of heterologous or homologous proteins in gram-positive microorganisms.

L'invention concerne la sécrétion dans les micro-organisme gram-positifs. Elle porte sur les séquences d'acide nucléique et d'acides aminés pour les facteurs de sécrétion SecDF chez Bacillus subtilis. L'invention concerne également des techniques améliorées permettant de favoriser la sécrétion de protéines hétérologues ou homologues dans les micro-organismes gram-positifs.

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