Improved fluorescent resonance energy transfer probes

Details Improved fluorescent resonance energy transfer probes Improved fluorescent resonance energy transfer probes

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2434356

The invention is directed to a pair of FRET hybridization probes hybridizing adjacently to a target nucleic acid sequence, each hybridization probe comprising (i) a nucleotide sequence entity which is substantially complementary to the sequence of the target nucleic acid, (ii) a fluorescent entity, said entity being either the FRET donor entity or the FRET acceptor entity, and (iii) a spacer entity connecting said nucleotide sequence entity and said fluorescent entity. According to one aspect of the invention, the intensity of fluorescence emission from the FRET donor entity and the intensity of fluorescence emission from the FRET acceptor entity is not substantially affected by any quenching activity of nucleotide residues either present in the sequence of the target nucleic acid or present in said nucleotide sequence entities of the hybridization probes.

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